Gefitinib and Methotrexate (GEM) clinical trials: testing a new medical treatment for ectopic pregnancy
In our laboratory, we have identified a novel medical treatment for ectopic pregnancy that could replace surgery for man...
Stephen is a clinician scientist: a specialist obstetrician who leads an internationally recognised research team, the Translational Obstetrics Group, at The University of Melbourne. After obtaining his FRANZCOG and PhD, he was appointed The Carl Wood Senior Lecturer (2007-2010, Monash University). During this period, he spent two years in The Centre for Cancer Research (now Hudson Institute) within the laboratory of Professor Bryan Williams.
He returned to Mercy Hospital for Women as an Associate Professor in 2011 where his team, The Translational Obstetrics Group, rapidly flourished. In recognition of his research achievements, Stephen was appointed Full Academic Professor in 2013 at the age of 39.
His academic achievements are recognized nationally and internationally, with over 110 publications. Most of these publications are leading specialty journals and prestigious interdisciplinary journals (e.g. RNA, Molecular Therapy, Journal of Immunology) and very high impact journals (Nature, The Lancet and British Medical Journal). He has published multiple times in prestigious journals such as Hypertension, Obstetrics and Gynecology, BMC Medicine, American Journal of Obstetrics and Gynecology, American Journal of Pathology, and Endocrinology.
Since 2010, he has attracted 11 National Health and Medical Research Council (NHMRC) project grants, including six as the principle investigator. One of these was selected by NHMRC as one of the ‘10 best project grants in 2015’, featured in 2016.
He has held the highest ranked applications for Clinical Career Development Fellowships I (2007) and II (2012) from NHMRC, and has received two NHMRC Achievement Awards. He has also obtained numerous grants from diverse funding bodies, and was a principal investigator on a grant obtained in the United Kingdom worth >2 million AUD. This now funds GEM III (Gefitinib and Methotrexate trial).
Stephen has had many invitations to deliver presentations at major scientific meetings across Australia and the across the world (Washington, Detroit, Sao Paulo, Santiago, Edinburgh, Munich and others). He has been on the Scientific Program Committee a number of national conferences, and co-led the sell-out Mercy Global Obstetric Update, Melbourne (2015).
Stephen has served many times on the NHMRC Grant Review Panel (this panel assesses major grant applications) and the NHMRC Academy. He has previous been Associate Editor for Molecular Human Reproduction, one of the top journals in the field
Stephen is heavily invested in training the clinician scientists of the future. He mentors students and early career researchers. His team - The Translational Obstetrics Group - boasts the highest number of obstetricians who have undertaken/or who are undertaking higher research degrees in the country. He also provides strong support and mentorship to his early and mid-career scientists.
The Translational Obstetrics Group (TOG), is a large research team of 10-15 scientists and clinician-scientists. Led by Stephen, TOG comprises two subgroups; each are led by senior scientists – Natalie Hannan, and Tu’uhevaha Kaitu’u-Lino.
The Translational Obstetrics Group is committed to laboratory discoveries that can be translated to the clinic, improving the lives and health of mothers and their babies worldwide. The three key concepts conceived by TOG have progressed from laboratory studies to international multi-centre trials and prospective studies. Any one of these—if successful—could be landmark discoveries, potentially resulting in leaps in global women’s and children’s health.